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Metformin

Metformin

Metformin is a trusted prescription medication used to help manage type 2 diabetes. It works by improving the body’s response to insulin and lowering glucose production in the liver, which helps regulate blood sugar levels.

Beyond blood sugar control, Metformin is often chosen for its role in supporting weight management and overall metabolic health. My Simple Med provides convenient, discreet access to Metformin as part of a safe and effective diabetes care plan.

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Metformin
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What is Metformin?

Metformin is a well-known oral medication traditionally used to manage type 2 diabetes. In recent years, it has gained recognition in longevity and anti-aging medicine due to its impact on insulin sensitivity, mitochondrial health, inflammation, and cellular aging. As a caloric restriction mimetic, Metformin is now widely used off-label to support metabolic health, fat loss, and cellular resilience, with potential to reduce age-related diseases and improve health span.

Benefits:

  • Enhances insulin sensitivity and stabilizes blood sugar
  • May reduce visceral fat and improve body composition
  • Supports mitochondrial function and metabolic flexibility
  • May reduce the risk of age-related diseases (heart disease, cancer, cognitive decline)
  • Activates cellular repair pathways (AMPK, autophagy)

How does it work?

Metformin targets multiple aging-related pathways through metabolic regulation and mitochondrial support:

  1. AMPK Activation
    • Metformin activates AMP-activated protein kinase (AMPK), a key energy sensor that promotes fat oxidation, glucose uptake, and mitochondrial biogenesis—mimicking the effects of fasting.
  2. Insulin Sensitivity & Glycemic Control
    • It lowers circulating insulin and glucose levels, helping reduce systemic inflammation and oxidative stress, two hallmarks of aging and metabolic decline.
  3. mTOR Pathway Modulation
    • By inhibiting the mTOR pathway, Metformin slows down cellular overgrowth and supports autophagy—a crucial anti-aging process for cellular cleanup and repair.

How it works

Get your medication in 
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Take the health questionnaire

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Need help?

Frequently asked questions

What can I expect with Metformin treatment?

  • Start with500mg once daily, gradually titrate up to 1000–2000mg daily if tolerated
  • Week 1–2:Improved blood sugar and appetite control
  • Week 4+:Enhanced energy, fat loss, cognitive clarity
  • Full anti-aging and metabolic benefits seen with consistent, long-term use
  • Best when combined with fasting, low-glycemic nutrition, and exercise
  • Missed dose? Skip and resume at the next scheduled time—do not double up

What are the possible side effects of Metformin?

Common (Mild & Localized):
• Eye redness or dryness
• Darkening of the upper eyelid skin (reversible)
• Itchy sensation at application site

Less Common / Rare:
• Iris (eye color) darkening (more common with direct eye instillation—not lash application)
• Eyelash misdirection or unexpected hair growth near the application area
• Allergic reaction (rash, swelling)

Precautions:

  • Use only on the upper lash line, not lower lashes
  • Remove contact lenses before applying (can reinsert after 15 minutes)
  • Avoid getting product in the eye; if contact occurs, rinse with water
  • Use a new applicator for each eye to reduce risk of contamination

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